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The dsRNA segments of
infectious pancreatic necrosis virus (IPNV) strain Jasper
(genus Aquabirnavirus:
family Birnaviridae)
available
as a Word file : Last updated 16/11/2000
|
dsRNA
(Size, bp) |
Open reading
frames (ORFs) |
Protein
( ':
protein structure/ function) |
Size >aa=
(kDa ) |
protein copy
number per particle |
location |
Function
|
|
Segment
A
(3092)
|
120-3035
|
polyprotein |
972
(106) |
- |
cytoplasm |
Polyprotein
precursor of viral proteins VP2, NS and VP3, exact sites of cleavage of
polyprotein are unknown.
|
|
pre
VP2
VP2 |
491
(62)
(54) |
-
- |
virion
virion |
pre VP2
cleaved to produce VP2, both forms found in
virion. VP2 is major capsid protein, type
specific and neutralising antigen. O-linked
glycosylation
|
|
NS |
221 |
-
|
non-structural |
Apparently
unique protease, active site at carboxy end, NS processed to NSt and NSta |
|
VP3
|
235
(30) |
- |
internal
capsid |
Group
specific antigen |
|
68-511 |
VP5
|
148
(17) |
- |
|
Positively
charged non-structural protein, from separate ORF. Anti apoptosis protein
(1) |
|
Segment B
(2784) |
101-2638 |
VP1
(Pol,
VPg) |
845
(94) |
- |
Virion,
both
as free and genome-linked forms |
Semi
conservative RNA dependent
RNA polymerase , protein covalently linked to 5’ end of both genome
segments, via terminal ‘G’ residue (VPg). VP1 can self guanylate,
which may provide a starting point for RNA chain elongation but there
is no evidence for capping or guanylyltransferase activity.
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' :
To facilitate comparisons of proteins across species, genera and families,
protein structure / function indicators can be added to protein names: (Pol) =
RNA polymerase; Genome linked protein = (VPg)
(The RNAs and Proteins of dsRNA
Viruses: Edited by Peter. P. C. Mertens and Dennis H.
Bamford)
References
1:
Hong JR, Gong HY, Wu JL. (2002 ) IPNV VP5, a novel anti-apoptosis gene of the Bcl-2 family, regulates Mcl-1
and viral protein expression. Virology 295: 217-29.
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